Tuesday, April 24, 2012

Vitamin D Newsletter

Vitamin D Newsletter
April 24, 2012
Is this email not displaying correctly?
View it in your browser.

 

Vitamin D Council

April 24th , 2012

Mercola tanningBioTech Supplements
This newsletter is in part made possible by the support of our sponsors
 
Correction of vitamin D deficiency improves seizure control in epilepsy
April 18, 2012 -- Brant Cebulla
Correction of vitamin D deficiency could help control seizures in epilepsy, according to a recently published study by a group of researchers in Hungary.

Holló A, Clemens Z, Kamondi A, Lakatos P, Szűcs A. Correction of vitamin D deficiency improves seizure control in epilepsy: A pilot study. Epilepsy and Behavior. 2012 Apr 11.

Lead investigator András Holló and company measured baseline levels of vitamin D in 13 subjects. Ten of the subjects had localization-related epilepsy, two had Lennox-Gastaut syndrome and one subject was diagnosed with idiopathic generalized epilepsy. The subjects’ ages ranged between 19-60 years and had epilepsy from 10 to 42 years. Median serum levels at baseline were 11.8 ng/ml, ranging from less than 4 ng/ml to 34.2 ng/ml. Eight of the patients had levels less than 12 ng/ml.

The investigators corrected deficiency in all 13 subjects by administering a one-time 40,000-200,000 IU dose of vitamin D3 to treat deficiency, and then administering a 2,000-2,600 IU daily dose of vitamin D3 for 3 months. The aim of treatment was to raise levels above 30 ng/ml. After a three month follow-up, the median 25(OH)D level was 38 ng/ml, ranging from 23.3-45 ng/ml.

They compared the number of seizures in this 3 month period with the 3 month period beforehand. The results were as follows:

  •     10 of the 13 subjects exhibited a decrease in number of seizures
  •     2 of the 13 subjects exhibited an increase in number of seizures
  •     One of the subjects had exactly the same number of seizures
  •     Overall, there was a median seizure number reduction of 40%, and this was statistically significant (p=.04)
  •     A seizure reduction of greater than 50% was experienced in five patients
  •     In the subject who started with a level less than 4 ng/ml and raised their level to 43.1 ng/ml, they experienced a reduction in number of seizures from 450 to 30 over three month intervals
The authors offered no mechanistic explanation for the results. They did point out that vitamin D receptors and enzyme activators are present in the brain. In the patient who had a level lower than 4 ng/ml and 450 seizures in three months, you can’t help but speculate that low serum calcium may have played a role in that subject’s seizure frequency.

Study limitations include small number of patients and lack of a placebo to compare to. This study certainly warrants a randomized controlled trial, and it also highlights the importance of correcting vitamin D deficiency in epilepsy patients. There is no harm in treating vitamin D deficiency, and this pilot study shows that epilepsy patients could be much better off with a simple maintenance dose of vitamin D.

The Vitamin D Council recommends a maintenance dose of 5,000 IU/day for adults and 1,000 IU/day for every 25lbs of body weight in children to sustain vitamin D sufficiency.


Click here to comment on this blog


Study shows link between vitamin D levels and risk of developing pre-eclampsia
April 17, 2012 -- John Cannell, MD

Dr Cannell reviews new research conducted by Dr. Shu Qin Wei and colleagues which shows a relationship between vitamin D levels in the third trimester of pregnancy and risk of developing pre-eclampsia, an inflammatory disorder responsible for 25% of all deaths of pregnant women. Continue reading (membership required)

Vitamin D for infants
April 20, 2012 -- John Cannell, MD

Dr. Cannell reviews a study from a Polish group that examine if the 400 IU daily vitamin D recommendation for infants is adequate. Continue reading (membership required)

Dietary vitamin D intake and sun exposure linked to lower risk of Alzhiemer's in France
April 23, 2012 -- Dr William Grant

Dr Grant reviews a recent study showing an association between vitamin D status and risk of developing Alzheimer’s disease. Continue reading (open access)



Connect with VDC!
Stay up to date with the latest news and research about vitamin D and join in on the converesation by following us on Twitter or liking us on Facebook! Also, use our new sharing tool on the left side of our blog page to share articles with your friends.

Copyright © 2012 The Vitamin D Council, All rights reserved.
You are receiving this because you signed up to regular email newsletters on the Vitamin D Council website.

Our mailing address is:
The Vitamin D Council
1241 Johnson Ave. #134
San Luis Obispo, CA 93401

Add us to your address book